Peter Thornton Fox, M.D.

Principal Investigator, Shenzhen Institute of Ne

Professor Fox is a neurologist with a career-long research focus on functional and structural brain imaging. He has worked extensively with positron-emission tomography (PET), with functional and structural magnetic resonance imaging (fMRI and sMRI), and with magnetic spectroscopy (MRS) throughout his career. For the past 24 years (1991-present) he has served as Director of the Research Imaging Institute (RII), a department-level, research-dedicated component of the University of Texas Health Science Center at San Antonio. In this capacity, he has overseen the steady transformation of the RII from a facility focused on human neuroimaging research to a truly translational facility supporting multi-modal (PET, MRI, MRS) imaging in rodents (mice, rats) and multiple non-human primate species (NHP; marmosets, capuchins, rhesus, baboons and chimpanzees) as well as humans. This expansion of capacity creating a Comprehensive Facility for Animal Imaging Research (CFAIR) -- was funded by > $10 million in facility-development grants from the Texas Emerging Technology Fund (ETF), the Defense Advanced Research Projects Agency (DARPA), the NIH Shared Instrumentation Grant (S10) and Institutional Animal Resource (G20) programs. While the majority of his research experience is in humans, he has numerous publications using NHP models and has been funded as on NHP grants both as PI and as co-I. The NIH/NIBIB, NIH/NIMH, NIH/NINDS, NIH/NIDCD, NIH/NLM, NIH/NHLBI, The National Science Foundation, The Office of Naval Research, The Veterans Administration, the CDMRP, The Army MRMC, DARPA, The Dana Foundation, The McDonnel-Pugh Foundation, The San Antonio Area Foundation, and The Kronkosky Foundation have funded his imaging research.

Selected Publications:

  1. Fox, P. T., Mintun, M. A., Raichle, M. E., & Herscovitch, P. (1984). A noninvasive approach to quantitative functional brain mapping with H2 (15) O and positron emission tomography. J Cereb Blood Flow Metab, 4(3), 329-33.
  2. Fox, P. T., Raichle, M. E., & Thach, W. T. (1985). Functional mapping of the human cerebellum with positron emission tomography. Proceedings of the National Academy of Sciences, 82(21), 7462-7466.
  3. Fox, P. T., & Raichle, M. E. (1986). Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proceedings of the National Academy of Sciences, 83(4), 1140-1144.
  4. Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M., & Van Essen, D. C. (1986). Mapping human visual cortex with positron emission tomography.
  5. Fox, P. T., Miezin, F. M., Allman, J. M., Van Essen, D. C., & Raichle, M. E. (1987). Retinotopic organization of human visual cortex mapped with positron-emission tomography. The Journal of neuroscience, 7(3), 913-922.
  6. Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., & Raichle, M. E. (1988). Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature, 331(6157), 585-589.
  7. Posner, M. I., Petersen, S. E., Fox, P. T., & Raichle, M. E. (1988). Localization of cognitive operations in the human brain. Science, 240(4859), 1627-1631.
  8. Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988). Nonoxidative glucose consumption during focal physiologic neural activity. Science, 241(4864), 462-464.
  9. Reiman, E. M., Fusselman, M. J., Fox, P. T., & Raichle, M. E. (1989). Neuroanatomical correlates of anticipatory anxiety. Science, 243(4894), 1071-1074.
  10. Petersen, S. E., Fox, P. T., Snyder, A. Z., & Raichle, M. E. (1990). Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. Science, 249(4972), 1041-1044.
  11. Pardo, J. V., Fox, P. T., & Raichle, M. E. (1991). Localization of a human system for sustained attention by positron emission tomography. Nature, 349(6304), 61-64.
  12. Fox, P. T., & Woldorff, M. G. (1994). Integrating human brain maps. Current Opinion in Neurobiology, 4(2), 151-156.
  13. Fox, P. T., & Lancaster, J. L. (1994). Neuroscience on the net. Science (New York, NY), 266(5187), 994.
  14. Parsons, L. M., Fox, P. T., Downs, J. H., Glass, T., Hirsch, T. B., Martin, C. C., ... & Lancaster, J. L. (1995). Use of implicit motor imagery for visual shape discrimination as revealed by PET.
  15. Fox, P. T., Ingham, R. J., Ingham, J. C., Hirsch, T. B., Downs, J. H., Martin, C., ... & Lancaster, J. L. (1996). A PET study of the neural systems of stuttering.
  16. Gao, J. H., Parsons, L. M., Bower, J. M., Xiong, J., Li, J., & Fox, P. T. (1996). Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science, 272(5261), 545-547.
  17. Denton, D., Shade, R., Zamarippa, F., Egan, G., Blair-West, J., McKinley, M., & Fox, P. T. (1999). Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst. Proceedings of the National Academy of Sciences, 96(5), 2532-2537.
  18. Liu, Y., Gao, J. H., Liotti, M., Pu, Y., & Fox, P. T. (1999). Temporal dissociation of parallel processing in the human subcortical outputs. Nature,400(6742), 364-367.
  19. Parsons, L. M., Denton, D., Egan, G., McKinley, M., Shade, R., Lancaster, J., & Fox, P. T. (2000). Neuroimaging evidence implicating cerebellum in support of sensory/cognitive processes associated with thirst. Proceedings of the National Academy of Sciences, 97(5), 2332-2336.
  20. Fox, P. T., Ingham, R. J., Ingham, J. C., Zamarripa, F., Xiong, J. H., & Lancaster, J. L. (2000). Brain correlates of stuttering and syllable production. Brain, 123(10), 1985-2004.
  21. Parsons, L. M., Egan, G., Liotti, M., Brannan, S., Denton, D., Shade, R., ... & Fox, P. T. (2001). Neuroimaging evidence implicating cerebellum in the experience of hypercapnia and hunger for air. Proceedings of the National Academy of Sciences, 98(4), 2041-2046.
  22. Brannan, S., Liotti, M., Egan, G., Shade, R., Madden, L., Robillard, R., ... & Fox, P. T. (2001). Neuroimaging of cerebral activations and deactivations associated with hypercapnia and hunger for air. Proceedings of the National Academy of Sciences, 98(4), 2029-2034.
  23. Liotti, M., Brannan, S., Egan, G., Shade, R., Madden, L., Abplanalp, B., Robillard, R., Lancaster, J., Zamarripa, F.E., Fox, P. T. and Denton, D. (2001). Brain responses associated with consciousness of breathlessness (air hunger). Proceedings of the National Academy of Sciences, 98(4), 2035-2040.
  24. Farrell, M. J., Zamarripa, F., Shade, R., Phillips, P. A., McKinley, M., Fox, P. T., ... & Egan, G. F. (2008). Effect of aging on regional cerebral blood flow responses associated with osmotic thirst and its satiation by water drinking: a PET study. Proceedings of the National Academy of Sciences, 105(1), 382-387.
  25. Laird, A. R., Eickhoff, S. B., Li, K., Robin, D. A., Glahn, D. C., & Fox, P. T. (2009). Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling. The Journal of Neuroscience, 29(46), 14496-14505.
  26. Kochunov, P., Glahn, D., Winkler, A., Duggirala, R., Olvera, R. L., Cole, S., Dyer, T. D., Almasy, L., Fox, P. T. and Blangero, J. (2009). Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume. Stroke, 40(12), 3685-3690.
  27. Eickhoff, S. B., Jbabdi, S., Caspers, S., Laird, A. R., Fox, P. T., Zilles, K., & Behrens, T. E. (2010). Anatomical and functional connectivity of cytoarchitectonic areas within the human parietal operculum. The Journal of neuroscience, 30(18), 6409-6421.
  28. Lin, A. L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J. H. (2010). Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex. Proceedings of the National Academy of Sciences, 107(18), 8446-8451.
  29. Karlsgodt, K. H., Kochunov, P., Winkler, A. M., Laird, A. R., Almasy, L., Duggirala, R., Olvera, R. L., Fox, P. T., Blangero, J. and Glahn, D. C. (2010). A multimodal assessment of the genetic control over working memory. The Journal of Neuroscience, 30(24), 8197-8202.
  30. Kochunov, P., Glahn, D., Lancaster, J., Winkler, A., Kent, J. W., Olvera, R. L., ... & Fox, P. T. (2010). Whole brain and regional hyperintense white matter volume and blood pressure overlap of genetic loci produced by bivariate, whole-genome linkage analyses. Stroke, 41(10), 2137-2142.