Huan Chen, Ph. D

Associate Investigator, Shenzhen Institute of Neuroscience

Dr. Huan Chen received her PhD in biology from the Second Military Medical University in China.  She joined National Center for Protein Sciences (Beijing) as an Associate Professor.  Dr Chen's main research interest is gene mutations and altered gene expression in language disorders (such as dyslexia and stuttering).

Selected Publications:

  1. Lu S, Jiao H, Xu J, Zheng Y, Sun Y*, Chen H* (corresponding authors). Downregulation of IL6 Targeted MiR-376b May Contribute to a Positive IL6 Feedback Loop During Early Liver Regeneration in Mice. Cell Physiol Biochem, 2015; 37(1):233-242.
  2. Jiao H, Zhu Y, Lu S, Zheng Y*, Chen H* (corresponding authors). An Integrated Approach for the Identification of HNF4α-Centered Transcriptional Regulatory Networks During Early Liver Regeneration. Cell Physiol Biochem. 2015;36(6):2317-2326.
  3. Chen H, Xu J, Zhou Y, Gao Y, Wang G, Xia J, Huen M, Siok W, Jiang Y, Tan L, Sun Y: Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population. BMC genetic, 2015; 16:7.
  4. Chen H, Wang G, Xia J, Zhou Y, Gao Y, Xu J, Huen MS, Siok WT, Jiang Y, Tan LH, Sun Y: Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population. Behav Brain Funct, 2014; 10:29.
  5. Chen H, Lu S, Zhou J, Bai Z, Fu H, Xu X, et al. Integrated Approach for the Identification of USF1-centered Transcriptional Regulatory Networks during Liver Regeneration. BBA - Gene Regulatory Mechanisms, 2014, 1839: 415-423.
  6. Chen H, Sun Y, Dong R, Yang S, Pan C, Xiang D, et al. Mir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation. PLoS One, 2011, 6(5): e20238.
  7. Chen H, Yang S, Yang Z, Ma L, Jiang D, Mao J, et al. Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J Cell Biochem, 2007, 102(5): 1281-1289.
  8. Zheng Y, Chen H (co-first), Yin M, Ye X, Chen G, Zhou X, Yin L, Zhang C, Ding B: MiR-376a and Histone Deacetylation 9 Form A Regulatory Circuitry in Hepatocellular Carcinoma. Cell Physiol Biochem, 2015; 35:729-739.
  9. Fu H, Xu H, Chen H (co-first), Li Y, Li W, Zhu Q, et al. Inhibition of Glycogen Synthase Kinase 3 Ameliorates Liver Ischemia/Reperfusion Injury via an Energy-dependent Mitochondrial Mechanis. J Hepatol, 2014, 61:816-824.
  10. Fu H, Chen H (co-first), Wang C, Xu H, Liu F, Guo M, et al. Flurbiprofen, a cyclooxygenases Inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3beta signaling and mitochondrial permeability transition. Mol Med, 2012, 18:1128-1135.
  11. Pan C, Chen H (co-first), Wang L, Yang S, Fu H, Zheng Y, et al. Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration. PLoS One, 2012, 7(6): e39151.
  12. Zhao Y, Chen H (co-first), Shang Z, Jiao B, Yuan B, Sun W, et al. SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway. Mar Drugs, 2012, 10(6): 1345-1359.