刁昱文

副研究员

: diaoyuwen@sions.cn; diaoyuwen@szu.edu.cn 

刁昱文,深圳市神科学研究院副研究2012年获得吉林大学医学专业博士。主要研究方向是瘤的靶向治,抗瘤靶向的作用机制研究,瘤的免疫治TOLL 受体的免疫调节机制及其在抗瘤效果的研究。

代表性论文:

  1. Fu L, Qin YR, Ming XY, Zuo X, Diao Y (共同第一), Zhang LY, Ai J, Liu BL, Huang TX, Cao TT, Tan BB, Xiang D, Zeng CM, Gong J, Zhang QC, Dong SS, Chen J, Liu H, Wu JL, Qi RZ, Xie D, Wang LD, Guan XY. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancerPNAS, 2017 May 22. 
  2. Diao Y, Wang X, Wan Y, Zhong J, Gao D, Liu Y, Gao N, Li W, Liu B, Huang X, Jin Z, Peng B, Wang Z, Fu L, Chen S, Jin G. Antitumor activity of a novel small molecule TLR7 agonist via immune response induction and tumor microenvironment modulation. Oncol Rep. 2016,35(2):793-800. 
  3. Wang X, Diao Y (共同第一), Liu Y, Gao N, Gao D, Wan Y, Zhong J, Jin G. Synergistic Apotosis-inducing Effect of Aspirin and Isosorbide Mononitrate on Human Colon Cancer Cells. Mol. Med Rep. 2015,12(3):4750-8. 
  4. Diao Y, Han W, Zhao H, Zhu S, Liu X, Feng X, Gu J, Yao C, Liu S, Sun C, Pan F. Designed synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge-modification and incorporation of the integrin αvβ3 homing domain [J], Journal of Peptide Science, 2012,18:476-486. 
  5. Du Y, Du T, Shi Y, Zhang A, Zhang C, Diao Y, Jin G, Zhou EM. Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages. Antiviral Res. 2016,131:9-18. 
  6. Gao D, Diao Y, Li W, Gao N, Liu Y, Wang Z, Jiang W, Jin G. Toll-Like Receptor 7 Inactive Ligands Enhanced Cytokine Induction by Conjugation to Weak Antigens. ChemMedChem, 2015,10(6), 977-980.
  7. Gao D, Liu Y, Diao Y, Gao NN, Wang ZL, Jiang WQ, Jin GY. Synthesis and evaluation of conjugates of novel TLR7 inert ligands as self-adjuvanting immunopotentiators. ACS Med. Chem. Lett. 2015,6(3): 249-253.
  8. Lin G, Wang X, Yi W, Zhang C, Xu G, Zhu X, Cai Z, Liu Y, Diao Y, Lin MC, Jin G. A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma. J Transl Med. 2015,13:166.
  9. Zhao H., Feng X., Han W., Diao Y., Han D., Tian X., Gao Y., Liu S., Zhu S., Yao C., Gu J., Sun C., Lei L. Enhanced binding to and killing of hepatocellular carcinoma cells in vitro by melittin when linked with a novel targeting peptide screened from phage display. Journal of peptide science: an official publication of the European Peptide Society 2013,19, 639-650.
  10. Liu S, Han W, Sun C. Lei L, Feng X, Yan S, Diao Y, Gao Y, Zhao H, Yao C, Liu Q. Subtractive screening with the Mycobacterium tuberculosis surface protein phage display library [J]. Tuberculosis 2011,91, 579-586.